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Structural Aspects of Infectious Disease

8—10 August 2016

Robinson College, Cambridge, UK

Eric Sundberg (University of Maryland School of Medicine, U.S.A.)
Susan Lea (Sir William Dunn School of Pathology, United Kingdom)
Brian Baker (University of Notre Dame, U.S.A.)
Monday 8 August 2016
10:00 - 10:45 Registration and coffee

10:45 - 11:00 Welcome and Introduction

Session 1: Antigen Presentation and Recognition

Monday 8 August 2016
11:00 - 11:45
Determinants of TCR binding geometries and the consequences for receptor specificity
Brian Baker (University of Notre Dame, U.S.A.)
11:45 - 12:00
The molecular mechanism of T cell receptors binding to MHC class II proteins
Selected Oral Communication – Esam Abualrous (Free University Berlin)
12:00 - 12:15
Novel structural parameters of IG-Ag complexes yield a quantitative description of interaction specificity and binding affinity
Selected Oral Communication – Frederic Cazals (INRIA, France)
12:15 - 13:00
TCR-MHC interactions
Andrew Sewell (Cardiff University School of Medicine, United Kingdom)
13:00 - 14:00 Lunch

14:00 - 14:45
Antigen presentation
Sebastian Springer (Jacobs University Bremen, Germany)
14:45 - 15:00
Structural and functional insight in the Helicobacter pylori blood group antigen binding adhesin BabA
Selected Oral Communication – Kristof Moonens (Free University Brussels)

Session 2: Immunity

Monday 8 August 2016
15:00 - 15:45
Complement structure and function
Susan Lea (Sir William Dunn School of Pathology, United Kingdom)
15:45 - 16:00
Unravelling the molecular basis of adhesion to the host via Als1, a major virulence factor from Candida albicans
Selected Oral Communication – Inmaculada Perez-dorado (Imperial College London)
16:00 - 16:30 Coffee/tea break

16:30 - 17:15
Structure of the complement membrane attack complex
Doryen Bubeck (Imperial College London, United Kingdom)
17:15 - 17:30
Neutralization of Argentine hemorrhagic fever virus: different means to the same end
Selected Oral Communication – Antra Zeltina (University of Oxford)
17:30 - 17:45
PilN binding modulates the structure and binding partners of PilM in the Pseudomonas aeruginosa Type IVa Pilus system
Selected Oral Communication – Matthew McCallum (University of Toronto)
17:45 - 19:00 Poster Session

Session 3: Host Receptors

Tuesday 9 August 2016
09:00 - 09:45
Regulation of immune signalling by TRIM proteins
Katrin Rittinger (The Francis Crick Institute, United Kingdom)
09:45 - 10:00
Investigating structural drivers of antigen specificity
Selected Oral Communication – Nishant Singh (University of Notre Dame)
10:00 - 10:15
Emergent paramyxovirus with zoonotic potential utilizes a novel host cell entry pathway
Selected Oral Communication – Ilona Rissanen (University of Oxford)
10:15 - 10:45 Coffee/tea break

10:45 - 11:30
Immunoglobulins and their receptors, and subversion of their protective roles by pathogens
Jenny Woof (University of Dundee Medical School, United Kingdom)
11:30 - 11:45
Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion.
Selected Oral Communication – Steinar Halldorsson (Wellcome Trust Centre for Human Genetic)
11:45 - 12:00
Structural insights into clathrin binding by viral and cellular proteins
Selected Oral Communication – Julia Muenzner (University of Cambridge)
12:00 - 12:45
Vaccine and entry-inhibitor design for RSV
Jason McLellan (Dartmouth College, U.S.A.)
12:45 - 14:00 Lunch

Session 4: Microbial pathogenesis I

Tuesday 9 August 2016
14:00 - 14:45
Structural and Molecular Biology of Bacterial Secretion Systems
Gabriel Waksman (Birkbeck, United Kingdom)
14:45 - 15:00
Catch-bond mechanism of the bacterial adhesin FimH
Selected Oral Communication – Roman Jakob (University of Basel)
15:00 - 15:15
Examining the Mechanism of Pore Formation by Intermedilysin: A Structural and Biophysical Approach
Selected Oral Communication – Miss Courtney Boyd (Imperial College London)
15:15 - 15:45 Coffee/tea break

15:45 - 16:30
Cryo-tomographic studies of the evolution of high-torque bacterial flagellar motors in gastrointestinal pathogens
Morgan Beeby (Imperial College London, United Kingdom)
16:30 - 17:15
Structure and function of the flagellar capping protein
Eric Sundberg (University of Maryland School of Medicine, U.S.A.)
17:15 - 18:00
Near-atomic resolution cryo-EM analysis of bacterial appendages
Edward Egelman (University of Virginia, U.S.A.)
18:00 - 19:30 Poster Session

19:30 Conference Dinner

Session 5: Microbial pathogenesis II

Wednesday 10 August 2016
09:00 - 09:45
Roles for the HIV-1 capsid during the early stages of infection
David Jacques (MRC Laboratory of Molecular Biology, United Kingdom)
09:45 - 10:00
Selected Oral Communication slot from poster abstracts – TBC
10:00 - 10:15
Crystal structure of the P. aeruginosa amyloid subunit transporter FapF
Selected Oral Communication – Sarah Rouse (Imperial College London)
10:15 - 10:45 Coffee/tea break

10:45 - 11:30
Structural insights into the amyloid secretion channel FapF from Peudomonas aeruginosa
Steve Matthews (Imperial College London, United Kingdom)
11:30 - 11:45
TIE proteins: chemical harpoons for covalent host:bacteria interactions
Selected Oral Communication – Ulrich Schwarz-Linek (University of St Andrews)
11:45 - 12:30
Host cell interactions and biofilm formation mediated by surface proteins of Gram positive bacteria
Jennifer Potts (University of York, United Kingdom)
12:30 - 12:45 Concluding remarks

12:45 Meeting closes, packed lunch and departure