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Structural Aspects of Infectious Disease

8—10 August 2016

Robinson College, Cambridge, UK



Organizers:
Eric Sundberg (University of Maryland School of Medicine, U.S.A.)
Susan Lea (Sir William Dunn School of Pathology, United Kingdom)
Brian Baker (University of Notre Dame, U.S.A.)
Monday 8 August 2016
10:00 - 10:45 Registration and coffee

10:45 - 11:00 Welcome and Introduction

Session 1: Antigen Presentation and Recognition

Monday 8 August 2016
11:00 - 11:45
Determinants of TCR binding geometries and the consequences for receptor specificity
Brian Baker (University of Notre Dame, U.S.A.)
11:45 - 12:00
The molecular mechanism of T cell receptors binding to MHC class II proteins
Selected Oral Communication – Esam Abualrous (Free University Berlin)
12:00 - 12:15
Novel structural parameters of IG-Ag complexes yield a quantitative description of interaction specificity and binding affinity
Selected Oral Communication – Frederic Cazals (INRIA, France)
12:15 - 13:00
TCR-MHC interactions
Andrew Sewell (Cardiff University School of Medicine, United Kingdom)
13:00 - 14:00 Lunch

14:00 - 14:45
Antigen presentation
Sebastian Springer (Jacobs University Bremen, Germany)
14:45 - 15:00
Structural and functional insight in the Helicobacter pylori blood group antigen binding adhesin BabA
Selected Oral Communication – Kristof Moonens (Free University Brussels)

Session 2: Immunity

Monday 8 August 2016
15:00 - 15:45
Complement structure and function
Susan Lea (Sir William Dunn School of Pathology, United Kingdom)
15:45 - 16:00
Unravelling the molecular basis of adhesion to the host via Als1, a major virulence factor from Candida albicans
Selected Oral Communication – Inmaculada Perez-dorado (Imperial College London)
16:00 - 16:30 Coffee/tea break

16:30 - 17:15
Structure of the complement membrane attack complex
Doryen Bubeck (Imperial College London, United Kingdom)
17:15 - 17:30
Neutralization of Argentine hemorrhagic fever virus: different means to the same end
Selected Oral Communication – Antra Zeltina (University of Oxford)
17:30 - 17:45
PilN binding modulates the structure and binding partners of PilM in the Pseudomonas aeruginosa Type IVa Pilus system
Selected Oral Communication – Matthew McCallum (University of Toronto)
17:45 - 19:00 Poster Session

Session 3: Host Receptors

Tuesday 9 August 2016
09:00 - 09:45
Regulation of immune signalling by TRIM proteins
Katrin Rittinger (The Francis Crick Institute, United Kingdom)
09:45 - 10:00
Investigating structural drivers of antigen specificity
Selected Oral Communication – Nishant Singh (University of Notre Dame)
10:00 - 10:15
Emergent paramyxovirus with zoonotic potential utilizes a novel host cell entry pathway
Selected Oral Communication – Ilona Rissanen (University of Oxford)
10:15 - 10:45 Coffee/tea break

10:45 - 11:30
Immunoglobulins and their receptors, and subversion of their protective roles by pathogens
Jenny Woof (University of Dundee Medical School, United Kingdom)
11:30 - 11:45
Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion.
Selected Oral Communication – Steinar Halldorsson (Wellcome Trust Centre for Human Genetic)
11:45 - 12:00
Structural insights into clathrin binding by viral and cellular proteins
Selected Oral Communication – Julia Muenzner (University of Cambridge)
12:00 - 12:45
Vaccine and entry-inhibitor design for RSV
Jason McLellan (Dartmouth College, U.S.A.)
12:45 - 14:00 Lunch

Session 4: Microbial pathogenesis I

Tuesday 9 August 2016
14:00 - 14:45
Structural and Molecular Biology of Bacterial Secretion Systems
Gabriel Waksman (Birkbeck, United Kingdom)
14:45 - 15:00
Catch-bond mechanism of the bacterial adhesin FimH
Selected Oral Communication – Roman Jakob (University of Basel)
15:00 - 15:15
Examining the Mechanism of Pore Formation by Intermedilysin: A Structural and Biophysical Approach
Selected Oral Communication – Miss Courtney Boyd (Imperial College London)
15:15 - 15:45 Coffee/tea break

15:45 - 16:30
Cryo-tomographic studies of the evolution of high-torque bacterial flagellar motors in gastrointestinal pathogens
Morgan Beeby (Imperial College London, United Kingdom)
16:30 - 17:15
Structure and function of the flagellar capping protein
Eric Sundberg (University of Maryland School of Medicine, U.S.A.)
17:15 - 18:00
Near-atomic resolution cryo-EM analysis of bacterial appendages
Edward Egelman (University of Virginia, U.S.A.)
18:00 - 19:30 Poster Session

19:30 Conference Dinner

Session 5: Microbial pathogenesis II

Wednesday 10 August 2016
09:00 - 09:45
Roles for the HIV-1 capsid during the early stages of infection
David Jacques (MRC Laboratory of Molecular Biology, United Kingdom)
09:45 - 10:00
Selected Oral Communication slot from poster abstracts – TBC
10:00 - 10:15
Crystal structure of the P. aeruginosa amyloid subunit transporter FapF
Selected Oral Communication – Sarah Rouse (Imperial College London)
10:15 - 10:45 Coffee/tea break

10:45 - 11:30
Structural insights into the amyloid secretion channel FapF from Peudomonas aeruginosa
Steve Matthews (Imperial College London, United Kingdom)
11:30 - 11:45
TIE proteins: chemical harpoons for covalent host:bacteria interactions
Selected Oral Communication – Ulrich Schwarz-Linek (University of St Andrews)
11:45 - 12:30
Host cell interactions and biofilm formation mediated by surface proteins of Gram positive bacteria
Jennifer Potts (University of York, United Kingdom)
12:30 - 12:45 Concluding remarks

12:45 Meeting closes, packed lunch and departure