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Protein S-palmitoylation: from Mechanism to Application

21—23 September 2016

St Hilda's College, Oxford, UK



Organizers:
William Fuller (University of Dundee, United Kingdom)
Piers Hemsley (University of Dundee and the James Hutton Institute, United Kingdom)
Wednesday 21 September 2016
13:00 - 14:00 Registration

14:00 - 14:15 Welcome and Introduction

Session 1: Regulating Reversible S-palmitoylation

14:15 - 14:45
Mechanism and Function of zDHHC S-Palmitoyltransferases
Maurine Linder (Cornell University, U.S.A.)
14:45 - 15:15
Substrate selectivity in the zDHHC family of S-acyltransferases
Luke Chamberlain (University of Strathclyde, United Kingdom)
15:15 - 15:30
Agonist-induced S-palmitoylation of a novel site within the β2-adrenergic receptor is associated with a novel intracellular itinerary and mechanism of receptor desensitization
Selected Oral Communication - Naoko Adachi (Kobe University)
15:30 - 16:00 Refreshment Break

16:00 - 16:30
Identification of novel protein depalmitoylases that regulate palmitate turnover on N-Ras
Elizabeth Conibear (Centre for Molecular Medicine and Therapeutics, Canada)
16:30 - 16:45
Structural features of the acyl protein thioesterases APT1 and APT2 discriminate isoform-selective competitive inhibitors
Selected Oral Communication - Sang Joon Won (University of Michigan)
16:40 - 17:00
Dynamics of a palmitoylation cascade
Selected Oral Communication - Laurence Abrami (epfl)
17:00 - 17:30 Flash Poster Presentations

17:30 - 19:00 Poster Session 1

19:00 Dinner

Session 2: Regulation of Cellular Function by S-palmitoylation

09:00 - 09:30
Unpicking the workings of the cell surface acyl transferase DHHC5
William Fuller (University of Dundee, United Kingdom)
09:30 - 10:00
S-acylation and cell specific control of ion channel physiology
Michael Shipston (University of Edinburgh, United Kingdom)
10:00 - 10:15
Control of cancer growth and drug sensitivity byEGFR palmitoylation
Selected Oral Communication - Eric Witze (University of Pennsylvania School of Medicine)
10:15 - 10:30
Autophagy proteins are getting fat: Emergence of palmitoylation as a regulator of autophagy and neurodegeneration
Selected Oral Communication - Dale Martin (University of British Columbia)
10:30 - 11:00 Refreshment Break

11:00 - 11:30
DHHC9 in the development and function of neuronal circuits
Shernaz Bamji (University of British Columbia, Canada)
11:30 - 12:00
S-acylation in plants - the same but different
Piers Hemsley (University of Dundee & The James Hutton Institute, United Kingdom)
12:00 - 12:15
An essential role for palmitoylation in neurodevelopmental axon degeneration
Selected Oral Communication - Gareth Thomas (Temple University School of Medicine)
12:15 - 12:30
Dynamic S-acylation of the SNARE protein SNAP25
Selected Oral Communication - Jennifer Greaves (University of Strathclyde)
12:30 - 12:45
Breaking news and paper highlights (3 minute max talks submitted at registration)
12:45 - 13:45 Lunch

Session 3: New Tools and Approaches

13:45 - 14:15
Identification and modeling of palmitoylation systems
Gisou van der Goot (Ecole Polytechnique Fédérale de Lausanne, Switzerland)
14:15 - 14:45
Challenges and emerging approaches for targeting protein interfaces in Wnt signaling
Rami Hannoush (Genentech, Inc., U.S.A.)
14:45 - 15:00
Blocking substrate recruitment by DHHC-protein acyl transferase enzymes for therapeutic gain
Selected Oral Communication - Niall Fraser (University of Dundee)
15:00 - 15:30 Refreshment Break

15:30 - 16:00
APT2 inhibition restores Scribble localization and S-palmitoylation in Snail-transformed cells
Selected Oral Communication - Brent Martin (University of Michigan)
16:00 - 16:15
The molecular mechanism of a conserved regulatory region in zDHHC PAT C-termini
Selected Oral Communication - Krishna Reddy (University of South Florida)
16:15 - 16:30
Mass-tag labeling reveals site-specific and endogenous levels of protein S-fatty acylation
Selected Oral Communication - Emmanuelle Thinon (The Rockefeller University)
16:30 - 17:00
Emerging methods, requests for help and collaboration (3 minute max talks submitted at registration)
17:00 - 18:30 Poster Session 2

19:00 Conference Dinner

Session 4: S-palmitoylation Interplay with Membrane Dynamics

09:30 - 10:00
Ankyrin-G, zDDH5, and zDDHC8 and the Control of Plasma Membrane Dynamics
Paul Jenkins (University of Michigan, U.S.A.)
10:00 - 10:30
Palmitoylation-dependent membrane domains and endocytosis in cell stress
Donald Hilgemann (UT Southwestern, U.S.A.)
10:30 - 10:45
TBC
10:45 - 11:15 Refreshment Break

11:15 - 11:30
Regulation of the plant V-ATPase by S-acylation
Selected Oral Communication - Upendo Lupanga (University of Heidelberg)
11:30 - 11:45
Metabolic stress alters the balance between palmitoylation and glutathionylation of the Na pump regulatory protein phospholemman
Selected Oral Communication - Jacquie Howie (University of Dundee)
11:45 - 12:00
Exploring the links between the ZDHHC9 gene and intellectual disability
Selected Oral Communication - Marianna Kouskou (University of Strathclyde)
12:00 - 12:30 Concluding Remarks

12:30 Lunch and Depart