Deubiquitylases and Ubl-proteases: from fundamental principles to therapeutic opportunities 2023

19-21 June 2023

South Hall Venue, University of Edinburgh

Abstract deadline:  20 April 2023

Earlybird registration deadline: 20 April 2023

Registration is now open! Accommodation is limited. Please note that once accommodation is full and no longer possible for delegates to book during the registration process, individuals will need to find their own accommodation. 

The post-translational modification of proteins with ubiquitin and ubiquitin-like proteins (UBLs) is essential to protein turnover, but also acts in the transduction of cellular signals. Deubiquitylating enzymes (DUBs) can ensure protein stability and modulate signaling cascades such as DNA repair pathways. This is the third in a series of international meetings that uniquely focuses on DUBs and related proteases deconjugating UBLs. We will explore the structure and function of DUBs, with a view to understanding their specificity and relationship to interesting biological pathways, including examples drawn from the microbiological world impacting on infection. The meeting will reflect that DUBs have emerged as intriguing new therapeutic targets in cancer research, neurodegenerative conditions and beyond. A series of highly selective inhibitors have been developed and first in class drugs targeting DUBs have now entered clinical trials. Exciting new therapeutic opportunities are envisaging DUBs as targets for hetero-bifunctional molecules, aimed at recruiting select DUBs for the purpose of targeted protein stabilisation. 

This meeting will bring together leading academic researchers in the DUB/ULP area with their counterparts in biotech and pharma, in order to initiate, and further, collaborative research. This is also an excellent opportunity for young researchers (including students and post-docs) to showcase their work.

Programme Coordinators for this event are: 

Michael Clague, University of Liverpool

Yogesh Kulathu, University of Dundee

Sylvie Urbe, University of Liverpool

Oral communication slots are available at this meeting. All attendees, particularly researchers in the early stages of their career, are invited to submit a poster abstract for consideration as an oral communication. You can submit your abstract here.

Register now! Limited places available

Event sponsored by:

Biochemical Journal logo

Biosynth: formerly Cambridge Research Biochemicals logo
 

Entact Bio logo
Journal of Cell Science logo

 

Stablix logo


UbiQ logo
 
 Ubiquigent logo
 

There are a number of sponsorship and exhibition opportunities available for this meeting. For more details, contact Hannah Atkins, Sponsorship Manager.

Biochemical Society Bursaries

We offer a wide variety of bursaries to help you attend this event and save money on registration fees! Apply during the registration process for any of the following schemes:

Full, Early Career, and Student Bursaries: We offer bursaries of up to £300 to support the attendance of Full, Early Career, and Student members at our face-to-face and online scientific meetings, training events, and courses.

General Travel Grants: Funding of up to £750 is available to support attendance at scientific meetings, training courses, or lab visits. Available for Postgraduate, Early Career, Full, and Emeritus members. 

Care and Assistance Grants: We recognise that care needs and requirements can vary from individual to individual. These grants provide additional funding to cover participation in a Society meeting or training course. The grant is open to all additional support needs, including but not limited to, carer support, childcare, disability, and accessibility needs.

Stay Connected Bursaries: If you are currently on a career break, or have recently returned to work, these bursaries make it easier for members to remain engaged with the scientific community by covering the registration fees. Requests for financial support towards accommodation and travel will also be considered.

Online Attendance Grants: These grants are available to cover the livestream registration fee at a Society meeting. 

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