Mutations in Leucine-Rich Repeat Kinase 2 (LRRK2) are the most common genetic cause of Parkinson’s disease (PD), responsible for up to 2-3% of all PD cases in the UK and up to 40% in some populations. Coupled with its clear genetic links to PD, LRRK2’s status as a complex, multi-domain kinase has led to this protein being flagged as one of the most promising drug targets for Parkinson’s disease.
The field is witnessing major advances in our understanding of the function of LRRK2 and its role in human disease and is the focus for this year’s biennial scientific meeting on LRRK2.
The conference programme will explore the genetic forms of PD, the LRRK2 gene and the LRRK2 protein, as well as the basic LRRK2 signalling mechanisms and physiological and pathological functions of LRRK2. In addition, non-neuronal LRRK2 signalling, particularly with respect to neuroinflammation and the immune system in PD, will be covered, as well as the role of LRRK2 in non-PD conditions.
We are welcoming abstracts for both oral communications and poster presentations, from both industry and academia and across all career stages. The meeting will be of particular interest to those working in biochemistry, neuroscience, biotechnology and pharmaceuticals.
09 May - 13 May
FEBS3+ Meeting: 86th Harden Conference – Machines on Genes
From bacteria to eukaryotes, cells have evolved a remarkable battery of enzymes to deal with the mechanical and topological challenges presented by nucleic acid production, processing and maintenance. A clear view of the biology of the genetic material requires a molecular understanding of how these enzymes function. Such an understanding will enhance our ability to manipulate genome structure and gene expression.
The theme of this meeting revolves around the mechanisms of these enzymes, with particular emphasis on research that integrates structural, biochemical, biophysical and computational approaches. With recent technological advances in imaging (i.e., single-molecule and cryo-electron microscopies), we expect to witness a flourish of key biological systems to be characterised with unprecedented detail.
The meeting will cover many of the molecular mechanisms by which large macromolecular machines carry out a diverse range of nucleic acid processes including DNA replication and repair, gene transcription and regulation, RNA processing and splicing, translation, nucleic acids structures and chromatin structure and epigenetic mechanisms. The meeting will also explore new quantitative techniques as well as theoretical approaches.
Translation is an essential highly conserved process which is required for the synthesis of proteins in both prokaryotic and eukaryotic cells. This unique annual UK scientific meeting enable discussing the latest progress in this field and fostering collaborations between researchers.
This year’s meeting will cover a wide range of topics related to translation, including:
mechanistic basis of regulation
upstream signal transduction cascades
ribosome structure and function
structure of translation factors/complexes and regulatory factor
genome-wide investigation of translation
RNA/tRNA modifications and localisation
The conference is also an important forum for young researchers at PhD and postdoctoral levels, providing opportunities for to deliver oral and poster presentations to promote their research. As part of the programme, we will host a dedicated Early Career Researcher event to promote further networking amongst this group.
The application of styrene-maleic acid (SMA) co-polymers to extract small discs of membrane, termed SMA lipid particles (SMALPs), has changed the established landscape of research in biological membranes. Membrane proteins play a vital role in cellular communication and the control of transport across the membrane, making them key therapeutic targets for many human diseases. Their location within the membrane, tightly packed with so many different proteins and lipids has, until now, made them extremely challenging to study. By allowing membrane proteins to be purified and studied whilst maintaining their lipid environment, the SMALP methodology enables the study of membrane protein structure and function using techniques that were previously impractical.
New applications of SMALPs are rapidly emerging making membrane protein study more accessible and widespread. This meeting will explore the latest developments within the field, including novel polymers, techniques and targets, bringing together a wide range of researchers to share their findings.
This is a joint between The Biochemical Society and The British Society for Research on Ageing (BSRA).
Increased age is the major risk factor for multiple diseases including cancer, diabetes, cardiovascular disease and neurodegeneration. Given the current global demographic shift, in which there will be over 2.1 billion people aged over 60 by 2050, new strategies to improve health in older people are urgently needed.
Research has shown that common underlying biological processes, such as nutrient signalling and cellular metabolism, drive multiple age-related pathologies; these biological mechanisms of ageing have therefore emerged as viable therapeutic targets for the treatment of age-related diseases. Metabolic dysfunctions during ageing are now considered major causative factors for such diseases.
This conference will bring together those working on cellular metabolism with those developing interventions to improve healthy ageing, providing an interdisciplinary forum for discussing how to translate fundamental scientific findings into clinical strategies that target ageing and its associated disease.
Without a template, the biosynthesis of glycans heavily relies on the organisation of enzymes in the Golgi apparatus. In addition, glycan functions often feedback on important basic cell biological processes such as membrane trafficking and signalling. Therefore, understanding the interfaces between intracellular organisation and glycobiology is crucial to provide new tools and understanding for the functional investigation of glycans.
This scientific meeting will bring together glycoscientists with cell biologists to foster new ideas and collaborations between both disciplines. A range of topics from traditional cell and glycobiology through analytics and synthetic carbohydrate chemistry all the way to systems level studies will be explored at the event to encourage more joined-up thinking.