88th Harden Conference: Beyond catalysis – kinases and pseudokinases 2022
Kinases and pseudokinases fulfil allosteric, scaffolding, molecular switch and decoy roles in cell signalling. The recent attention on pseudokinases has shone a light on under-appreciated non-catalytic functions that can be mediated by kinases, raising the prospect that novel and specific therapeutics could target these functions.
2021 marks the 30th anniversary of the publication of the first protein kinase structure (Knighton et al, Science 1991). Much of our understanding of these diverse proteins has emanated from this structure, providing an important context for this meeting and a milestone to be celebrated.
This topic is the theme of the 88th Harden Conference, an event series unique to the Biochemical Society, providing residential research conferences covering a specialist topic. These events are widely recognised for their emphasis on free and open discussion to encourage the exchange of the latest data and a critical discussion of the technical challenges that these developments face.