Adventures in lipid research: bioactive lipids of inflammation and coagulation
At this webinar we will hear from the 2022 Morton Lecture winner, Professor Valerie O’Donnell at Cardiff University, UK.
Valerie O’Donnell (PhD, FMedSci) is a biochemist whose research is focused on using mass spectrometry for identification of lipid mediators of inflammation. For the last 15 yrs she has studied how modified phospholipids generated by circulating vascular cells regulate vascular inflammation and thrombosis.
She particularly focused on molecular species of lipids termed enzymatically-oxidized phospholipids (eoxPL) made by platelets, neutrophils, monocytes and eosinophils which were identified in her group. Mice that lack the lipids are unable to mount a normal clotting response in vivo. The detailed biochemical and biophysical mechanisms of action of eoxPL were characterised. Her group also showed that eoxPL can regulate neutrophil antibacterial actions and transcriptional activation in monocytes in vitro, suggesting they are a central part of innate immunity.
Other areas of current interest are delineating how oxylipins are removed during inflammation. Her team recently published the first lipidomic characterization of the viral envelope of SARS-CoV2. During her Award lecture, Professor O’Donnell will discuss her latest lipid research.