Deubiquitinases – from structure to physiology 2017


Deubiquitinases (DUBs) are key components of the ubiquitin system, and play major roles in important physiological processes, in particular in protein turnover and cell signalling. Indeed, ubiquitin modifications can take many forms: in addition to single modification (monoubiquitination), ubiquitin can form polymers through eight distinct linkage points (polyubiquitination), and ubiquitin can also cross-talk with other posttranslational modifications such as phosphorylation and ubiquitin-like modifications. DUBs tackle this complex protein modification system in a highly sophisticated manner.

Recent years have seen great progress in assigning specific DUBs to biological pathways and in understanding the structural underpinning of their activity, specificity and regulation. Moreover, DUBs are emerging as a novel class of druggable targets in cancer, neurodegeneration, infection and inflammation. This conference provided the first international meeting dedicated to this class of enzymes, encompassing structural, physiological and translational aspects. It brought together international leaders in the field together with early stage researchers, in a setting and atmosphere aimed at fostering collegiality and collaboration. In addition to invited speakers, a number of talks were selected from the submitted abstracts.

Michael Clague (University of Liverpool, United Kingdom)
David Komander (MRC Laboratory of Molecular Biology, United Kingdom)

Session 1: Structure and mechanism of DUBs

Monday 26 June 2017
13:00 – 13:45 Registration and Lunch

13:45 – 14:00 Welcome and Introduction

14:00 – 14:35
Titia Sixma (Netherlands Cancer Institute, Netherlands)
14:35 – 14:55
Mechanism and Regulation of the Lys6-selective Deubiquitinase USP30
Selected Oral Communication – Malte Gersch (MRC LMB, Cambridge, United Kingdom)
14:55 – 15:30
Elton Zeqiraj (University of Leeds, United Kingdom)
15:30 – 16:00 Refreshment Break

16:00 – 16:30
EMBO YIP Lecture: Yogesh Kulathu (University of Dundee, United Kingdom)
16:30 – 16:50
A novel CA-clan DUB with unusual properties.
Selected Oral Communication – Thomas Hermanns (University of Cologne)
16:50 – 17:20
Aude Echalier (University of Leicester, United Kingdom)
17:20 – 18:00
Keynote Speaker – Daniel Finley (Harvard Medical School, U.S.A.)
18:00 – 19:00 Poster Session 1


Session 2: Cell Biology of Deubiquitylases

Tuesday 27 June 2017
09:00 – 09:35
Alan D’Andrea (Harvard, U.S.A.)
09:35 – 10:10
Sylvie Urbé (University of Liverpool, United Kingdom)
10:10 – 10:30
Understanding and targeting USP8 function in endocytosis
Selected Oral Communication – Marie-Odile Fauvarque (Biosciences and Biotechnology Institute of Grenoble, France)
10:30 – 11:00 Refreshment Break

11:00 – 11:35
EMBO YIP Lecture: Anna Sablina (University of Leuven (KU Leuven), Belgium)
11:35 – 11:55
Function of AMSH DUBs in Arabidopsis thaliana
Selected Oral Communication – Karin Vogel (University Konstanz)
11:55 – 12:15
How pathogenic bacteria subvert host ubiquitin signaling
Selected Oral Communication – Jonathan Pruneda (MRC Laboratory of Molecular Biology, United Kingdom)
12:15 – 12:50
Judy Coulson (University of Liverpool, United Kingdom)
13:00 – 14:00 Lunch


Session 3: Deubiquitylases in disease

Tuesday 27 June 2017
14:00 – 14:35
Mads Gyrd-Hansen (University of Oxford, United Kingdom)
14:35 – 15:10
Martin Eilers (University of Würzburg, Germany)
15:10 – 15:30
Regulation of the tumor suppressor complex BAP1-ASXL2 by ubiquitination
Selected Oral Communication – El Bachir Affar (Centre de Recherche, Hospital Maisonneuve-Rosemont)
15:30 – 16:00 Refreshment Break

16:00 – 16:35
Klaus-Peter Knobeloch (Freiburg, Germany)
16:35 – 16:55
The ubiquitin-specific protease USP5 is required for proteasome-dependent protein degradation in the myocardium
Selected Oral Communication – Mareike Poetsch (Max-Planck-Institute for Heart and Lung Research)
16:55 – 17:15
Ubiquitin dependent regulation of CYLD
Selected Oral Communication – Tencho Tenev (ICR)
17:15 – 17:35
Ubiqutin dependent unfoldase p97 and deubiquitinating enzyme Ataxin 3 regulate DNA damage response after ionizing radiation
Selected Oral Communication – Kristijan Ramadan (1Cancer Research UK/Medical Research Council Oxford Institute for Radiation Oncology)
17:35 – 18:30 Poster Session 2

19:30 Conference Dinner


Session 4: Therapeutic targeting of DUBs

Wednesday 28 June 2017
09:00 – 09:40
Ingrid Wertz (Genentech, United Kingdom)
09:40 – 10:15
Matthias Trost (University of Newcastle, United Kingdom)
10:15 – 10:30
Molecular basis of USP7 inhibition by selective small molecule inhibitors
Selected Oral Communication – Andrew Turnbull (Cancer Research Technology Ltd)
10:30 – 11:00 Refreshment Break

11:00 – 11:20
Usp8 modifies α-synuclein toxicity in Parkinson’s disease models by negatively regulating its lysosomal degradation.
Selected Oral Communication – George Tofaris (University of Oxford, United Kingdom)
11:20 – 11:40
Deubiquitinase Activity Profiling in Breast Cancer
Selected Oral Communication – Sijia Liu (Leiden University Medical Center (LUMC), Netherlands)
11:40 – 12:15
Huib Ovaa (Leiden University Medical Center (LUMC), Netherlands Sponsored by Cancer Research Technology)
12:15 Meeting Close and Packed Lunch


Jun 26 2017 - Jun 28 2017


All Day
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