Glycobiology in Infectious Disease

A Biochemical Society Focused Meeting

Topics covered in this meeting were invited to submit to our journal, Biochemical Society Transactions, or other publicationpublished by Portland Press, the wholly-owned trading subsidiary of the Biochemical Society.

Glycobiology is a major aspect of molecular and cellular biology. There is increasing interest in elucidatingthe roles of carbohydrate moieties in the establishment and progression of infectious diseases.

This two-day conference provided a platform for researchers investigating the multifactorial interface between glycobiology and the pathogenesis of parasites, viruses and bacteria.

Topics included:

·         New tools and techniques

·         Pathogenesis and disease

·         Interventions, targets and strategies

We encouraged delegates from all career stages to submit abstracts. In addition to invited speakers, a number of oral presentations were selected from the submitted abstracts. The organisers especially encouraged abstract submission from postgraduate and early career researchers.

Sarah Berry (Keele University, United Kingdom)
Helen Price (Keele University, United Kingdom)
Mark Skidmore (Keele University, United Kingdom)
Marissa Maciej-Hulme (Radboud University Nijmegen Medical Centre, Netherlands)
Monday 4 September 2017
09:30 – 10:45 Registration

10:45 – 11:00 Welcome and Introduction


Glycobiological Tools and Technologies I

Monday 4 September 2017
11:00 – 11:45
Discovery of a new carbohydrate-binding megavirus associated with toxin release from harmful algal blooms
Rob Field (John Innes Centre, United Kingdom)
11:45 – 12:05
Development and applications of lectins as biological tools in diagnosis of diseases.
Selected Oral Communication- Navkiran Kaur ((Amity Institute of Biotechnology, India)
12:05 – 12:25
Mimetic sugar nucleotides to probe a strategic bacterial dehydrogenase enzyme
Selected Oral Communication- Gavin J Miller (Keele University, UK)
12:25 – 13:30 Lunch/ Poster Session 1


Pathogenesis and Disease I

Monday 4 September 2017
13:30 – 14:15
Alvaro Acosta-Serrano (Liverpool School of Tropical Medicine, United Kingdom)
14:15 – 14:35
Glycoproteomics of the Clostridium difficile S-layer.
Selected Oral Communication- Laura Bouché (Imperial College London, UK)
14:35 – 14:55
Nuclear Magnetic Resonance and Molecular Dynamic Simulation of the interaction between recognition protein of the Influenza A virus and glycan cell surface receptors.
Selected Oral Communication- Stefano Elli (Ronzoni Institute, Italy)
14:55 – 15:40
Pharmaceutical heparin improves survival of human neural progenitor cells infected with ZIKA virus
Eliza Vicenzi (San Raffaele Scientific Institute, Italy)
15:40 – 16:15 Tea/ Coffee Break


Intervention, Targets and Strategies I

Monday 4 September 2017
16:15 – 17:00
The HIV glycan shield as a target for broadly neutralizing antibodies
Katie Doores (Kings College London, United Kingdom)
17:00 – 17:20
S. pyogenes Group A Carbohydrate: Investigating and targeting a virulence factor biosynthesis pathway.
Selected Oral Communication- Helge Dorfmueller (University of Dundee, UK)
17:20 – 17:40
Endo-α-1,2-mannosidase inhibition as a potential antiviral therapy method.
Selected Oral Communication- Lukasz F. Sobala (University of York, UK)
17:40 – 18:40 Poster Session 2

19:15 – 20:00 Research in Three Minutes” and Drinks Reception

20:00 Conference Dinner


Intervention, Targets and Strategies II

Tuesday 5 September 2017
09:00 – 09:45
Glycobiology of syndecan-1 in bacterial infections
Pyong Park (Harvard University, U.S.A.)
09:45 – 10:05
Exploiting the human anti-α-gal response to cutaneous leishmaniasis for diagnosis.
Selected Oral Communication- Victoria M. Austin (Liverpool School of Tropical Medicine, UK)
10:05 – 10:25
Novel covalent probes for a bacterial glycosyltransferase: discovery and applications.
Selected Oral Communication- Gerd K. Wagner (King’s College London, UK)
10:25 – 10:45
Analysis of heparan sulphate in the infection of host macrophages by Leishmania parasites.
Selected Oral Communication- Marissa Maciej-Hulme (Radboudumc, Netherlands)
10:45 – 11:10 Tea/ Coffee Break


Glycobiological Tools and Technologies II

Tuesday 5 September 2017
11:10 – 11:30
The unique polysialic acid binding of human adenovirus 52 – glycan microarray, structural insights and future implications
Selected Oral Communication- Yan Liu (Imperial College London, UK)
11:30 – 11:50
Development of bio-orthogonal fluorescent tags for carbohydrate analysis and functional assays.
Selected Oral Communication- Katarzyna Brzezicka (The Open University, UK)
11:50 – 12:10
Glycosylation of Trypanosome antigens in recombinant systems.
Selected Oral Communication- Barrie Rooney (University of Kent, UK)
12:10 – 12:55
Tim Rudd (National Institute for Biological Standards and Control, United Kingdom)
12:55 – 14:00 Lunch


Intervention, Targets and Strategies II

Tuesday 5 September 2017
14:00 – 14:20
TB Drug Targets in Mycobacterium tuberculosis α-Glucan Metabolism.
Selected Oral Communication- Sibyl F. Batey (John Innes Society, UK)
14:20 – 14:40
Pinpointing epithelial glycan receptors for rotaviruses by O-glycome beam search array approach
Selected Oral Communication- Zhen Li (Imperial College London, UK)
14:40 – 15:25
Michael Ferguson (University of Dundee, United Kingdom)
15:25 – 15:45 Closing Remarks and Depart


Sep 04 2017 - Sep 05 2017


All Day
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