Lipid Mediators in Ageing and Disease 2017

Enzymatic and non-enzymatic oxidation of polyunsaturated fatty acids leads to the formation of biologically active metabolites, known as lipid mediators. These can be exported extracellularly, and then sequestrated rapidly to stimulate cellular autocrine or paracrine pathways. Lipid mediators are involved in many physiological processes and their dysregulations have been observed in ageing and often linked to various lipid-based diseases such as diabetes, atherosclerosis, arthritis, cancer, Alzheimer’s disease and metabolic syndrome.


This focus group meeting aimed to bring together knowledge of lipid mediators across ageing and inflammatory diseases to underpin their importance to life sciences and clinical applications.

Irundika Dias (Aston University, United Kingdom)
Helen Griffiths (Aston University, United Kingdom)
Corinne Spickett (Aston University, United Kingdom)
Thursday 5 January 2017
Anna Nicolaou (The University of Manchester, United Kingdom)
09:00 – 09:50 Registration

09:50 – 10:00 Welcome and Introduction

10:00 – 10:40
Structural Elucidation of Novel Mediators in Resolution of Infectious Inflammation & Tissue Regeneration
Keynote Lecture- Charles Serhan (Brigham and Women’s Hospital/Harvard Medical School, U.S.A.)
10:40 – 11:00 Refreshment Break

11:00 – 11:30
Bioactive lipid mediators in the regulation of cutaneous inflammation
Anna Nicolaou (University of Manchester, United Kingdom)
11:30 – 11:50
Pro-resolving lipid mediators are critical in modulating T-helper cell responses: implications for modulation of chronic inflammation and autoimmunity
Selected Oral Communication- Valerio Chiurchiu (University of Rome, Italy)
11:50 – 12:10
Regulation of 5-lipoxygenase expression in inflammation and cancer
Selected Oral Communication- Dieter Steinhilber (University of Frankfurt, Germany)
12:10 – 12:30
Lipoxin A4 as a therapeutic in diabetes-associated atherosclerosis and kidney disease
Selected Oral Communication- Eoin Brennan (University College Dublin, Ireland)
12:30 – 13:00 Flash Poster Presentations

13:00 – 14:30 Lunch with Poster Session

14:30 – 15:00
Pharmacological inhibition of the proinflammatory action of phospholipid oxidation products
Valery Bochkov (University of Graz, Austria)
15:00 – 15:20
DHA-derived oxylipins, neuroprostanes and protectins, differentially and dose-depen dently modulate the inflammatory response in human macrophages: putative mechanisms through PPAR activation.
Selected Oral Communication- Cécile Gladine (INRA, France)
15:20 – 15:40
Maresin conjugates in tissue regeneration promote the clearance of bacterial infections and are organ protective
Selected Oral Communication- Jesmond Dalli (William Harvey Research Institute, United Kingdom)
15:40 – 16:10 Refreshment Break

16:10 – 16:40
Pro-resolving pathways to terminate inflammation and promote tissue repair
Mauro Perretti (University of London, United Kingdom)
16:40 – 17:10
Apoptotic Cell-derived Extracellular Vesicles – a matter of life and death.
Andrew Devitt (Aston University, United Kingdom)
17:10 – 17:30
Apoptotic cell-derived extracellular vesicles – defining the lipid mediator composition
Selected Oral Communication- Ivana Milic (Aston University, United Kingdom)
17:30 – 18:30 Drinks Reception

18:45 Conference Dinner

Friday 6 January 2017
09:00 – 09:30
Mapping the lipidomes of innate immune cells
Valerie O’Donnell (Cardiff University, United Kingdom)
09:30 – 10:00
Oxysterols in the progression of atherosclerosis and Alzheimer’s disease
Giuseppe Poli (University of Torino, Italy)
10:00 – 10:20
Statin intervention reduce circulating oxysterols in hypercholesterolemic patients
Selected Oral Communication- Irundika H Dias (Aston University, United Kingdom)
10:20 – 10:40
Quality of fish oil has an impact on lipid composition in intermediate and low density lipoprotein subclasses
Selected Oral Communication- Amanda Rundblad (Oslo and Akershus University College, Norway)
10:40 – 11:00 Refreshment Break

11:00 – 11:30
Midlife blood metabolites and cognition in the 1946 British birth cohort
Petroula Proitsi (University College London, United Kingdom)
11:30 – 11:50
Isoprostanoids profiling to study the muscle aging process of aged master athletes.
Selected Oral Communication- Justine Bertrand-Michel (Lipidomic facility Inserm, France)
11:50 – 12:10
Experimental approaches for studying the subcellular localization of lipid mediator biosynthetic proteins in situ
Selected Oral Communication- Jana Gerstmeier (Friedrich-Schiller-University Jena, Germany)
12:10 – 12:30
Resolvin E1 attenuates inflammatory signalling and related atrophy in skeletal muscle myotubes
Selected Oral Communication- Luke Baker (Loughborough University, United Kingdom)
12:30 – 13:00 Flash Poster Presentations

13:00 – 14:30 Lunch with Poster Session

14:30 – 15:00
Omega-3 fatty acids and inflammatory processes: From molecules to man
Philip C. Calder (University of Southampton, United Kingdom)
15:00 – 15:20
Odd-Chain Fatty Acids Predict Insulin Sensitivity in People with T2DM and Protect HepG2 Cells from Palmitate- Induced Insulin Resistance Via PPARα
Selected Oral Communication- John Ikwuobe (Aston University, United Kingdom)
15:20 – 15:40
The effect of obesity on adipose tissue fatty acid composition and lipid mediators, and their response to chronic marine omega-3 fatty acid supplementation: The BIOCLAIMS study at the University of Southampton.
Selected Oral Communication- Helena Fisk (University of Southampton, United Kingdom)
15:40 – 16:00 Closing Remarks and Depart


Jan 05 2017 - Jan 06 2017


All Day
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