Salary:  PhD studentship consisting of a €18K stipend per annum plus EU course fees
Contract type:  Fixed Term, 4-year Studentship
Location:  Dublin, Ireland

Application deadline:  July 24th, 2020

This PhD studentship will investigate how colonisation with an important member of the respiratory microbiome, Staphylococcus aureus, influences development of adaptive immune memory (expansion and activation of resident memory T cells) and also innate immune memory (modulation of monocyte/macrophage function and metabolic activity), and will determine if this induced memory influences the response to subsequent bacterial and viral infection. Knowledge gained will provide much-needed insights into the mechanism by which S. aureus modulates host immunity and facilitate the development of new vaccines and immunomodulatory therapies urgently required to treat pathogenic infections.

The PhD student will have the opportunity to work with state-of-the-art in vivo models of bacterial colonisation using gnotobiotic mice and will acquire technical expertise in immunology, microbiology and metabolism. The student will be encouraged to attend national and international conferences to present their research findings and will have the opportunity to publish in high impact journals. The student will join a wider team of both academic and clinical researchers investigating all aspects of S. aureus immunity.

The successful applicant will be expected to have a first-class honours degree or a high upper second in a biological subject (preferably with a significant immunology component). We are looking for a highly motived candidate with a strong background in cell biology and immunology, ideally in the context of infection.

To apply please submit a covering letter and CV (include the names and contact details of 2 referees) to rachel.mcloughlin@tcd.ie