Salary: Grade 6: £29,176 – £34,804 per annum
Contract type: The post is available for one year to start on September 1st 2021. The latest possible contract end date is 30th September 2022.

Applications are invited for a Research Assistant neuronal cell biologist to work at the Laboratory of Molecular Neurodegeneration at the Oxford Parkinson’s Disease Centre (OPDC) on a research project to target lysosomal biology working in induced pluripotent stem cell (iPSC)-derived neuronal models of Parkinson’s disease (PD).

This is an exciting opportunity to work on the discovery of novel therapeutics for PD. The post-holder will use human iPSC lines from Parkinson’s patients differentiated into dopamine neurons to investigate disease mechanisms and test new therapeutic targets. The project will be performed in collaboration with GSK and offers an exciting collaboration to work at the translational interphase of academic and industry target discovery.

Duties will include undertaking laboratory experiments; interpretation of data; imaging analysis; generation and study of iPSC-derived neurons and cell lines; preparation of data for publication; study of lysosomal biology in cellular models of Parkinson’s; contribute to wider project planning and determine the most appropriate methodologies to test hypotheses. You will have excellent practical experience of working with cell cultures and good knowledge of cellular models of neurodegenerative disease. The ability to innovate, trouble-shoot technical problems, be meticulous in practical work and in record keeping is essential.

Applicants must hold, or be near completion of, a BSc/MSc in a relevant area of research and have experience in cellular neuroscience, and molecular cell biology relevant to analysis of neuronal phenotypes.

The post is available for one year to start on September 1st 2021. The latest possible contract end date is 30th September 2022. The post-holder will be based in the Laboratory of Molecular Neurodegeneration, Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford.

Informal enquiries may be directed Professor Richard Wade-Martins >

Closing date for applications is midday on Wednesday 7th July 2021.

Interviews are likely to be held during the week commencing 19th July 2021.