Their activity state and functional effects are controlled and or mediated by several interacting proteins, including guanine nucleotide exchange proteins, GTPase Activating proteins, effector and motor proteins. Rab GTPase function is essential for a vast range of normal cellular physiological processes, ranging from Long Term Potentiation (LTP) to cellular uptake of glucose in response to insulin signalling.
In recent years, Rabs, or their interactors, have been implicated in a wide range of genetic diseases. Some examples include choroideremia, Niemann-Pick disease, Griscelli syndrome, cancer aggressiveness, Charcot-Marie-Tooth disease, X-linked mental retardation, Huntingtin’s disease, Alzheimer’s disease, Batten’s disease, osteopetrosis, Crohn’s disease, diabetic nephropathy, cardiomyopathy, Carpenter’s syndrome, Sjogren’s syndrome and platelet disorders.
Furthermore, they are implicated in a lengthening list of host/pathogen diseases involving viruses, bacteria and parasitic pathogens. Some examples of viral infections include; Influenza-, Dengue-, West Nile-, Foot & mouth-, Coxsackie-, Encephalitis-, Hepatitis C-, Respiratory Syncytial- , Measles-, Hantavirus and Human Immunodeficiency Virus. Examples of bacterial infections with which Rabs have been connected include Chlamydia, Brucella, Salmonella, Listeria, Helicobacter, Mycobacteria. Parasitic conditions with which the Rabs have been connected include Trypanosoma cruzei and brucei.
The meeting will include a keynote presentation on Rabs by Bruno Goud and review presentations on Ras and Rho proteins by Chris Marshall and Alan Hall, respectively.
This meeting will bring together researchers who work on the functional characterization of Rabs and / or their interacting proteins in either normal cellular physiology (health) or in diseases as well as an overview of Ras, Rho and Rab cellular function.
- Rab function in the healthy cell
- The interplay between Rabs and infectious disease processes
- Rabs and inherited diseases
- Review of Rho function
- Review of Ras function
Reviews by the speakers, based on their presentations at this major international meeting, will be published exclusively in Biochemical Society Transactions (Volume 40, part 6).
Abstract deadline: 9 April 2012.
Abstract submission is now closed. If you would like to submit an abstract please contact the Conference Office.
Earlybird registration deadline: 11 May 2012.
Registration is now closed.
Science Foundation Ireland Poster prizes and Oral communication prizes were awarded at this meeting. View the winners.
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Oral communication slots are available at this meeting. All attendees, particularly researchers in the early stages of their career, are invited to submit a poster abstract for consideration as an oral communication.
Student Bursaries are available for this meeting.
'Eureka Moments: making proteins, making a difference'. As part of our centenary celebrations, a number of the Society’s Honorary Members have been asked to talk about the important moments in their careers and the future of the discipline.
The third to be released is that of Greg Winter who spoke to Michael Neuberger and Brian Hartley about the important moments in his career and the future of the discipline. Watch the interview now!