This webinar delved into the role of ubiquitin to explore the currently unknown TRIM functions in physiology and disease, as well as present new strategies to treat and prevent mitochondrial disorders.

Jane’s presentation investigated parallel in cellulo, in vitro, and in silico structure-function analyses of the ubiquitin E3 ligase activity and RING domain structural characteristics of the whole TRIM protein family. This research revealed a number of ‘pseudoligases’ whose RING domains have undergone structural divergence, resulting in a disruption to their ability to catalyse ubiquitin transfer.

In Michele’s presentation, he revealed how suppression of the cytosolic ubiquitin-proteasome system by the mtDNA mutation permits the leak-through of a pathogenic allele, revealing how some mutations can evade QC systems to cause mtDNA diseases which affect ~1/8000 humans.

Speakers:

• Jane Dudley, The Francis Crick Institute, UK
• Michele Frison, University of Cambridge, UK

This webinar was chaired by Hannah Jones, Centre for Medicines Discovery, UK.