Acylation of intracellular and secreted proteins: mechanisms and functional outcomes
A Biochemical Society Scientific Meeting
Luke Chamberlain (University of Strathclyde, UK)
Tony Magee (Imperial College, UK)
Protein acylation events are crucial lipidation processes playing a fundamental role in cell physiology. Recently there has been a surge of interest in two acylation pathways: S-acylation, the modification of intracellular proteins by fatty acids attached to cysteine, and the acylation of secreted proteins including Ghrelin, Wnts and Hedgehogs. Although these two acylations occur on different sides of cell membranes and are catalysed by different enzyme families (zDHHC and MBOAT respectively), research into each pathway informs the other. These acylation pathways have seen important advances over recent years that make this meeting particularly timely, including: new insight into the enzymology and regulatory effects of these lipid modifications; seminal 3D structures of acylating enzymes; development of novel chemical biology-based methodologies that have supported new breakthroughs; and the identification of links between acylation and disease and the potential for pharmaceutical intervention.
The aims of the meeting were to provide a forum for the discussion of new discoveries in the field of protein acylation and to accelerate new discoveries by supporting the development of new collaborations and exchange of ideas and technical expertise. The specific learning objectives were:
- To highlight the structure and function of enzymes that catalyse S-acylation and the acylation of soluble secreted proteins
- To understand how the attachment of fatty acids onto proteins impacts their trafficking and function
- To dissect how cell physiology and intracellular signalling is regulated by protein acylation
- To understand how acylation enzymes can be targeted as a therapeutic strategy in a variety of disorders
- To exemplify how new chemical biology approaches and other technological developments can be used to advance discovery in the protein acylation field
Topics in this meeting were invited to submit to our journal, Biochemical Society Transactions, or other publication published by Portland Press, the wholly-owned trading subsidiary of the Biochemical Society.
Oral communication slots were available at this meeting.
All attendees, particularly researchers in the early stages of their career, were invited to submit a poster abstract for consideration as an oral communication.
Student Bursaries were available for this meeting.
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