The Burmann lab uses advanced high-resolution NMR approaches to decipher the dynamics and structural adaptations of a diversity of protein machines involved in cellular protein quality control as well as transcription associated processes.

Their work has revealed distinct steps in the allosteric regulation of different enzymes such as serine proteases of the HtrA family and DNA polymerases. These novel findings provide detailed mechanistic insights into enzymatic function at atomic resolution likely paving the way for the future design therapeutic compounds targeting these machines.

Invited speaker:

• Dr Björn Burmann, University of Gothenburg

This webinar was chaired by Dr Vicky Higman, University of Leicester.