BMP Signalling in Cancer II

A Biochemical Society Scientific Meeting

Abstract deadline: closed

Registration: closed

Earlybird registration deadline: 31 January 2018

BMPs (body morphogenetic proteins) are members of the TGF-β family, which bind to and activate multiple receptor serine/threonine kinases. The BMP pathway regulates tissue development and regeneration. It has become clear that BMP signalling can be co-opted for both tumour initiation and promotion. These effects are strongly related to its role in regulating stem cells. Like TGF-β, BMP signalling can act as a tumour suppressor or tumour promoter, dependent on the microenvironmental context. For example, overexpression of the antagonist, Gremlin1 can promote colorectal cancer, while activating mutations in the BMP receptor kinase ALK2 drive a fatal paediatric glioma.

The aim of this conference was to explore the mechanisms of BMP signal transduction and to discuss how genetic and epigenetic alterations result in aberrant signalling and how this leads to cancer. Microenvironmental control of cancer cell function is a research area of intense interest and as a key mesenchymal-epithelial signalling pathway, BMP signalling is emerging as a key therapeutic target. We aimed to discuss in detail how to manipulate the pathway, both positively and negatively with small molecules or biologics.

Topics in this meeting were invited to submit to our journal, Biochemical Society Transactions, or other publications published by Portland Press, the wholly-owned trading subsidiary of the Biochemical Society.

The deadline for Oral communication abstracts is now closed for this meeting. All attendees, particularly researchers in the early stages of their career, are invited to submit a poster abstract for consideration.

Student Bursaries were available for this meeting.

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Apr 03 2018 - Apr 04 2018

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St Anne's College
Oxford, UK
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