Cell Signaling and Intracellular Trafficking in Cancer Biology: Interplay, Targeting and Therapy

The interplay between cell signaling and intracellular trafficking is implicated in fundamental cellular processes including cell growth and motility, whereas aberrant membrane trafficking events and signaling pathways are frequently associated with malignant transformation and cancer.

The aim of this scientific conference was to merge advanced topics in cancer cell signaling together with emerging research themes in lipid metabolism, intracellular organelles and membrane trafficking. We discussed oncogenic pathways and signaling networks as therapeutic targets and highlight their regulation by endomembranes and trafficking events.

The attendants were exposed to the most advanced topics at the interface between oncogenic signaling and membrane trafficking including:

1. Phosphoinositides Signaling and conversion in the endolysosomal system
2. Lysosomal signaling, Iron Metabolism and Ferroptosis
3. RTK signaling and RTK-associated drug resistance (cMet, AXL, EGFR etc)
4. Non-receptor tyrosine kinases and integrin trafficking
5. System analysis of Signaling networks in cancer and targeted therapies.
6. EMT, Stemness, and Metastasis