Hear from a previous awardee!
"This grant allowed me to spend a week with the Geri lab, who are developing cutting-edge tools to perform proximity proteomics at super-resolution spatial scales (as low as 2 nm!). Whilst there, the team showed me how to generate the photocatalysts and diazirine probes, conjugate catalysts to antibodies, perform blue light proximity reactions with their custom designed photoreactor (giving me tips on how to build my own!), perform streptavidin enrichment and on-bead tryptic digestion using their automated robotic platform, followed by analysis of MS-data using their custom written analytical pipeline. I was able to generate data that I included in a recent grant application that, if funded, will allow me to start my own lab.
I also had the opportunity and privilege to see their ongoing work, which could be of huge interest to my future research interests, as well as share my own research with the team. Jacob and the team were fantastic hosts, and I plan to return in a few months to scale up my interaction with them, applying their technologies to assessing which cells within human blood interact with immune checkpoint antibodies with varying efficacy."
Jonathan Worboys, University of Manchester